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Published on: October 27, 2020
Changes of protein profile of human urine after long-term orbital flights
L Kh Pastushkova1, O A Valeeva, A S Kononikhin
1State Scientific Center of the Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow; Yu. A. Gagarin Research and Test Cosmonaut Training Center, Zvezdnyi Gorodok, Moscow Region; Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. lpastushkova@mail.ru.
Abstract:
We analyzed protein profile of urine samples obtained from 7 Russian cosmonauts (age 35-51 years), participants of space flights on the International Space Station lasting for 169-199 days. Gradient chromatography with linear increase of eluent proportion was carried out in a system consisting of an Agilent 1100 chromatograph (Agilent Technologies Inc.) and a hybrid mass-spectrometer LTQ-FT Ultra (Thermo). The obtained results help to understand changes in the human body induced by space flight factors.
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