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Nanoneedle-assisted delivery of site-selective peptide-functionalized DNA nanocages for targeting mitochondria and
1Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
Small (Weinheim an Der Bergstrasse, Germany)
|December 11, 2013
Abstract:
Peptide-functionalized DNA nano-objects selectively target mitochondria and the nucleus by means of nanoneedle-assisted delivery. This technology preserves the cell viability and structural integrity of nanostructures and assists the nano-objects in escaping degradation by endocytosis. This method opens up a new avenue for further in vitro studies of intracellular behaviors of DNA assemblies and their interactions in specific organelles.

