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Association between birth order and emergency room visits and acute hospital admissions following pediatric

Steven Hawken1, Jeffrey C Kwong, Shelley L Deeks

  • 1ICES uOttawa, Ottawa, Ontario, Canada ; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada ; Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Plos One
|December 11, 2013
PubMed

Insights

First-born children experience more emergency room visits and hospital admissions after infant vaccinations compared to later-born siblings. This study highlights birth order as a factor in post-vaccination health events.

Area of Science:

  • Pediatric Health
  • Public Health
  • Epidemiology

Background:

  • Infant vaccinations are crucial for disease prevention.
  • Understanding post-vaccination adverse events is important for parental reassurance and healthcare planning.

Purpose of the Study:

  • To investigate the association between birth order and emergency room (ER) visits and hospital admissions following pediatric vaccinations.
  • To compare the incidence of post-vaccination events in first-born versus later-born infants.

Main Methods:

  • Utilized health administrative data from Ontario for children born between 2006 and 2009.
  • Employed a self-controlled case series design to analyze vaccination, ER visits, and hospital admission data.
  • Calculated relative incidence ratios (RIR) to compare first-born and later-born children.

Main Results:

  • First-born infants showed a higher relative incidence of ER visits and hospital admissions post-vaccination across all studied time points (2, 4, 6, and 12 months).
  • Specific RIRs indicated increased events for first-borns, such as 1.70 at 4 months (157 excess events/100,000) and 1.11 at 12 months (249 excess events/100,000).

Conclusions:

  • Birth order is significantly associated with an increased incidence of ER visits and hospitalizations following infant vaccinations.
  • First-born children consistently experienced a higher relative incidence of these events compared to their later-born counterparts.
Abstract

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