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T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

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Related Experiment Video

Updated: May 4, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Cross-presentation by human dendritic cell subsets.

Elodie Segura¹, Sebastian Amigorena¹

¹INSERM U932, 26 rue d'Ulm, 75005 Paris, France; Institut Curie, Section Recherche, 26 rue d'Ulm, 75005 Paris, France.

Immunology Letters

|December 17, 2013

Summary

This summary is machine-generated.

Human dendritic cells (DCs) are diverse antigen-presenting cells. This review examines human DC subsets and their specialized cross-presentation capabilities for activating CD8(+) T cells.

Keywords:

CD8+ T cells Cross-presentation Dendritic cells Vaccination

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

Immunology
Cell Biology

Background:

Dendritic cells (DCs) are key antigen-presenting cells with diverse subsets.
Murine DC subsets exhibit varied functions, including cross-presentation of exogenous antigens on MHC class I.
The specialization of human DC subsets in cross-presentation remains an active area of research.

Purpose of the Study:

To review identified human dendritic cell subsets.
To discuss recent findings on their antigen cross-presentation abilities.
To evaluate their efficiency in activating CD8(+) T cells.

Main Methods:

Literature review of human dendritic cell subsets.
Analysis of studies investigating cross-presentation mechanisms.
Evaluation of data on CD8(+) T cell activation by human DCs.

Main Results:

Human DCs comprise distinct subpopulations with differing phenotypes and functions.
Evidence suggests certain human DC subsets are specialized for cross-presentation.
The efficiency of these subsets in activating CD8(+) T cells varies.

Conclusions:

Human dendritic cell subsets possess specialized roles in antigen presentation.
Understanding these subsets is crucial for immunotherapy and vaccine development.
Further research is needed to fully elucidate their cross-presentation potential.