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Auditory Brainstem Responses (ABR) changes in children treated with high doses cisplatin.
The International Tinnitus Journal
|December 17, 2013
Summary
High-dose cisplatin chemotherapy in children can cause central auditory pathway neurotoxicity, specifically affecting brainstem pathways. Further research is needed due to the small sample size impacting statistical significance.
Area of Science:
- Pediatric Oncology
- Neuroscience
- Audiology
Background:
- Cisplatin chemotherapy is known to cause cochlear damage via oxidative stress.
- Limited research exists on cisplatin's neurotoxicity within the central auditory pathways.
Purpose of the Study:
- To investigate cisplatin-induced neurotoxicity in the central auditory pathways of children.
- Focus on children treated with high-dose cisplatin for solid malignant tumors.
Main Methods:
- Auditory brainstem response (ABR) and evoked otoacoustic emissions (EOA) were used.
- Thirteen children treated with cisplatin (60-120 mg/m(2)/cycle) were compared to 13 healthy controls.
- Auditory evaluation was also performed.
Main Results:
- Enlarged latencies of ABR waves I and V, and wave III were observed in some children.
- Increased interpeak intervals (I-III and III-V) were noted in a subset of patients.
- Evoked otoacoustic emissions remained normal, suggesting central, not peripheral, auditory system involvement.
Conclusions:
- Abnormal interpeak intervals in ABR suggest cisplatin neurotoxicity in brainstem auditory pathways.
- Normal EOA results support the conclusion of central auditory pathway damage.
- Statistical significance was limited, potentially due to the small study cohort.
