Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing Stage Transition Kinetics in Li-Graphite Intercalation Compounds by Time-Resolved In Situ Solid-State NMR via <sup>13</sup>C Labeling.

Journal of the American Chemical Society·2026
Same author

High Intensity Interval Training in Aged Female Mice Preserves Physical, Cognitive, and Cardiovascular Function.

bioRxiv : the preprint server for biology·2026
Same author

Mammogram geometric projection localization (MaGPL) for surgical body-surface localization of nonpalpable breast calcifications.

Gland surgery·2026
Same author

Oxidative Stress and Diminished Mitochondrial Proteostatic Reserve Are Linked to Enhanced mtUPR Initiation in Aged Mouse Muscle.

Aging cell·2026
Same author

Forecasting hourly foodservice sales during geopolitical and economical disruption using zero-inflated mixed effects models.

Journal of applied statistics·2026
Same author

Blast Resistance of Confined Multilayer Graded Corrugated-Core Sandwich Cylindrical Shells.

Materials (Basel, Switzerland)·2026

Related Experiment Video

Updated: May 4, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

988

Clinically relevant frailty index for mice.

Haiming Liu1, Ted G Graber1, Lisa Ferguson-Stegall1

  • 1Department of Physical Medicine and Rehabilitation, Program in Physical Therapy, University of Minnesota Medical School, Minneapolis.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|December 17, 2013
PubMed
Summary

Researchers developed a Frailty Index for aging mice, using grip strength, walking speed, activity, and endurance. This standardized approach identified frailty in mice, mirroring human clinical criteria and prevalence.

Keywords:
FrailtyMuscleSarcopenia.

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

18.6K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.6K

Related Experiment Videos

Last Updated: May 4, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

988
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

18.6K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.6K

Area of Science:

  • Gerontology
  • Animal Models

Background:

  • Frailty is a clinical syndrome linked to aging and negative health outcomes.
  • Existing research lacks standardized frailty assessment in animal models.

Purpose of the Study:

  • To develop a Frailty Index for 27- to 28-month-old C57BL/6 mice.
  • To align the mouse Frailty Index with clinical criteria used in humans.

Main Methods:

  • Assessed grip strength, walking speed, physical activity, and endurance in mice.
  • Utilized inverted-cling grip, rotarod, voluntary wheel running, and derived endurance tests.
  • Defined frailty as meeting three criteria below a 1.5 SD cutoff; mild frailty as two criteria.

Main Results:

  • One mouse was identified as frail, and one as mildly frail in the cohort.
  • Observed a 9% frailty prevalence, consistent with human populations at similar survival ages.
  • Validated the selected criteria and cutoff points for identifying frailty.

Conclusions:

  • The developed Frailty Index offers a standardized definition for frailty in mice.
  • This mouse model aligns with the operational definition of frailty in humans.
  • Provides a valuable tool for studying aging and frailty in preclinical research.