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Updated: Jun 23, 2026

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
09:19

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

High Intensity Interval Training in Aged Female Mice Preserves Physical, Cognitive, and Cardiovascular Function.

Drew Theobald, Phillip Williamson, Alexandra Johnston

    Biorxiv : the Preprint Server for Biology
    |June 22, 2026
    PubMed
    Summary

    High intensity interval training (HIIT) preserves physical, cognitive, and cardiovascular function in older female mice. This exercise intervention mitigates frailty and improves brain and heart health, offering a potential regenerative therapy for aging.

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    Area of Science:

    • Gerontology
    • Exercise Physiology
    • Cardiovascular Research

    Background:

    • Aging leads to declines in physical, cognitive, and cardiovascular function, impacting daily living and independence.
    • Exercise, particularly High Intensity Interval Training (HIIT), is a regenerative therapy that can counteract age-related functional loss.
    • Previous studies showed HIIT benefits in male mice, but its effects on older female mice were unknown.

    Purpose of the Study:

    • To investigate the effects of HIIT on physical, cognitive, and cardiovascular function in older adult female mice.
    • To determine if HIIT can mitigate frailty and improve brain and heart health in this demographic.
    • To compare outcomes between a HIIT group and a sedentary control group.

    Main Methods:

    • Older female mice (n=9) underwent 14 weeks of progressive HIIT or served as sedentary controls.
    • A comprehensive battery of tests assessed physical, cognitive, and cardiovascular function pre- and post-intervention.
    • Body composition, whole-body calorimetry, cardiac fibrosis, muscle fiber type, and hypothalamic IL-1β expression were also analyzed.

    Main Results:

    • HIIT significantly improved or preserved aerobic capacity, strength, motor function, and executive function compared to sedentary controls.
    • Exercise reduced systolic blood pressure and mean arterial pressure, decreased cardiac fibrosis, and increased Type 2a muscle fibers.
    • HIIT mitigated frailty onset and reduced hypothalamic IL-1β expression, indicating reduced inflammation.

    Conclusions:

    • High Intensity Interval Training (HIIT) effectively counteracts age-related declines in physical, cognitive, and cardiovascular function in older female mice.
    • HIIT demonstrates significant benefits for brain and heart health markers and prevents frailty onset.
    • This study highlights HIIT as a potent intervention for promoting healthy aging in females.