Related Experiment Video
Updated: May 4, 2026
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Mechanisms of cough
Peter G Gibson1, Jodie L Simpson, Nicole M Ryan
1aCentre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle bDepartment of Respiratory and Sleep Medicine, John Hunter Hospital cDepartment of Speech Pathology, John Hunter Hospital, New Lambton, New South Wales, Australia.
Recent developments in chronic cough mechanisms highlight laryngeal hypersensitivity (LHS). This new concept explains cough symptoms and guides effective therapies, including neuromodulators and speech pathology interventions.
Area of Science:
- Pulmonology
- Neuroscience
- Pharmacology
Background:
- Chronic cough affects global populations with regional variations in associated diseases.
- Validated questionnaires and objective tools can reliably measure cough frequency and reflex sensitivity.
Purpose of the Study:
- To review recent advancements in understanding the mechanisms of chronic cough.
Main Methods:
- Literature review of recent developments in chronic cough research.
- Analysis of diagnostic tools and therapeutic responses for different cough phenotypes.
Main Results:
- Eosinophilic bronchitis-associated cough responds to anti-inflammatory treatments.
- Neutrophilic bronchitis-associated cough is linked to rhinitis and GERD.
- Laryngeal hypersensitivity (LHS) emerges as a key concept explaining cough, identifying new pharmacotherapies targeting neural pathways and transient receptor channels, and supporting behavioral therapies for refractory cough.
Conclusions:
- New insights into cough mechanisms, particularly focusing on LHS, enhance the understanding of cough symptoms.
- LHS provides a framework for effective therapies, including speech pathology and neuromodulators, for chronic cough management.
Related Concept Videos
01:17Gross Anatomy of the Lungs
01:17Other Factors Affecting Respiration Centers
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical...
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:30Mechanism of Breathing I: Inspiration
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
01:23Mechanism of Breathing II: Expiration
Expiration, or exhaling, is a complex physiological process that begins as the inspiratory muscles begin to relax. This relaxation triggers a series of events that epitomize the efficiency of the respiratory system.
Mechanism of Expiration: