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Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Pattern electroretinography in glaucoma suspects and early primary open angle glaucoma.

Ebrahim Jafarzadehpour¹, Fatemeh Radinmehr¹, Mohammad Pakravan²

¹Department of Optometry, Faculty of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research

|December 19, 2013

Summary

Pattern electroretinography (PERG) reveals increased latency in retinal ganglion cell dysfunction for glaucoma suspects and early primary open angle glaucoma (POAG) patients. Amplitude reduction was only seen in early POAG, suggesting PERG detects dysfunction before cell loss.

Keywords:

Glaucoma Suspect Pattern Electroretinography Primary Open Angle Glaucoma

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Area of Science:

Ophthalmology
Neuroscience
Vision Science

Background:

Glaucoma is a leading cause of irreversible blindness.
Retinal ganglion cells (RGCs) are primarily affected in glaucoma.
Early detection of RGC dysfunction is crucial for timely intervention.

Purpose of the Study:

To investigate RGC dysfunction in glaucoma suspects and early primary open angle glaucoma (POAG) patients.
To utilize pattern electroretinography (PERG) for assessing RGC function.
To differentiate between early glaucomatous changes and normal aging.

Main Methods:

Recruited 20 glaucoma suspects, 15 early POAG patients, and 16 normal controls.
Recorded transient PERG using 0.8° and 16° checkerboard stimuli.
Measured P50 and N95 component amplitude and peak time, and N95 amplitude ratio.

Main Results:

Increased N95 peak time (latency) observed in both early POAG and glaucoma suspects compared to controls (P<0.001).
Reduced N95 amplitude and small/large check ratio in early POAG eyes (P<0.05).
No significant N95 amplitude reduction found in glaucoma suspects; P50 parameters showed no significant differences.

Conclusions:

PERG reveals uncoupled alterations in N95 peak time and amplitude in glaucoma.
Elevated N95 latency is an early indicator of RGC dysfunction in both suspects and POAG patients.
PERG may detect RGC dysfunction (latency increase) preceding cell death (amplitude decrease).