Related Experiment Video
Updated: May 4, 2026
09:39
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
9.2K
Syringeable self-assembled cyclodextrin gels for drug delivery
Susana M N Simões, Francisco Veiga, Juan J Torres-Labandeira
1Departamento de Farmacia y Tecnología Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain. Carmen.alvarez.lorenzo@usc.es.
Current Topics in Medicinal Chemistry
|December 21, 2013
Summary
Syringeable cyclodextrin (CD) gels offer minimally invasive drug delivery. These gels form depots at implantation sites, utilizing supramolecular systems for drug loading and controlled release.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Syringeable cyclodextrin (CD) gels are emerging materials for minimally invasive drug delivery and tissue engineering.
- They form depots at implantation sites, offering prolonged residence times.
- CD gels leverage supramolecular chemistry for their unique properties.
Purpose of the Study:
- To review the design and applications of syringeable cyclodextrin (CD) gels.
- To explore two main types of CD-based supramolecular gel systems.
- To analyze gelling mechanisms, influencing variables, and drug delivery applications.
Main Methods:
- Focuses on polypseudorotaxane formation via CD threading onto copolymers.
- Examines supramolecular assembly through CD-grafted polymers complexing with guest moieties.
- Discusses drug loading and stimuli-responsive release mechanisms.
Main Results:
- Two primary syringeable CD gel systems are detailed: polypseudorotaxanes and zipper-like assemblies.
- Both systems exhibit thixotropy, enabling syringeability and in-situ gelation.
- CD gels can load and stabilize drugs, with release influenced by physiological conditions.
Conclusions:
- Syringeable CD gels represent a promising platform for advanced drug delivery.
- Their tunable supramolecular structures allow for controlled drug release and depot formation.
- Further research into CD gel mechanisms and applications is warranted for therapeutic development.
More Related Videos
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
172
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
172
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137
01:11Oral Drug Delivery Systems: Delayed-Release Systems
222
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222