Related Experiment Video
Updated: May 4, 2026
07:08
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
1.7K
Advances in systemic therapy for advanced pancreatobiliary malignancies
Thorvardur R Halfdanarson1, Sigurdis Haraldsdottir2, Mitesh J Borad1
1Division of Hematology and Medical Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
F1000Research
|December 24, 2013
Summary
Pancreatobiliary cancers have a poor prognosis despite recent treatment advances. This review covers current options for advanced disease and highlights novel targeted therapies for improved patient survival.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Pancreatobiliary malignancies are rare with a poor prognosis.
- Current treatments for advanced disease include systemic therapy and radiation therapy for unresectable tumors.
Purpose of the Study:
- To review current treatment options for locally advanced pancreatobiliary malignancies.
- To highlight recent advances in systemic therapy, including targeted treatments.
Main Methods:
- Literature review of current treatment strategies.
- Analysis of recent advancements in systemic and targeted therapies.
Main Results:
- Despite advances, patient survival for pancreatobiliary cancers remains poor.
- Novel targeted treatments show promise for advanced disease.
Conclusions:
- Treatment for advanced pancreatobiliary malignancies is challenging.
- Further research into targeted therapies is crucial for improving outcomes.
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
563
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
563
01:30Acute Pancreatitis II: Clinical Manifestations and Management
1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K
01:21Chronic Pancreatitis II: Pathophysiology
30
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
30