Effects of ethanol on the functional properties of sodium channels in brain synaptosomes

Voltage-sensitive sodium channels in excitable cell membranes are responsible for the rapid increase in permeability to sodium ions that occurs during depolarization. Neurotoxins that bind with high affinity and specificity to voltage-sensitive sodium channels have been widely used to identify and characterize the structure and function of sodium channels in nerve and skeletal muscle. This chapter describes the actions of ethanol on the functional properties of voltage-sensitive sodium channels in mammalian brain nerve endings. The effects of acute and chronic ethanol administration are also reviewed. Alterations in the function of neuronal membrane sodium channels may be involved in the depressant effect of ethanol.