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Studies on Flowability, Compressibility and In-vitro Release ofTerminalia chebula Fruit Powder Tablets.

Singh Satya Prakash1, Niranjan Patra1, Chakraborty Santanu1

  • 1Division of Formulation and Development, PG Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur, Orissa, India.

Iranian Journal of Pharmaceutical Research : IJPR
|December 24, 2013
PubMed
Summary

Terminalia chebula fruit powder exhibits poor flowability and compressibility. Wet granulation and direct compression techniques significantly improve its powder properties for tablet formulation.

Keywords:
CompressibilityDissolution.FlowabilityTerminalia chebula

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Area of Science:

  • Pharmaceutical Technology
  • Pharmacognosy

Background:

  • Terminalia chebula dried fruit is traditionally used for its laxative effects.
  • The fruit powder exhibits inherent poor flowability, compressibility, and a mucilaginous nature, posing challenges for tablet formulation.

Purpose of the Study:

  • To evaluate the flowability and compressibility of Terminalia chebula fruit powder.
  • To develop stable tablet formulations using wet granulation and direct compression technologies.
  • To characterize the consolidation behavior and drug release profiles of the developed tablets.

Main Methods:

  • Powder characterization using Kawakita, Heckel, and Leuenberger equations to assess consolidation behavior.
  • Tablet formulation via wet granulation and direct compression.
  • Tannin content determination using UV spectrophotometry.
  • In-vitro dissolution studies in simulated gastric fluid (SGF).

Main Results:

  • Both wet granulation and direct compression improved powder cohesiveness and flowability.
  • Formulations exhibited enhanced compressibility, reaching maximum crushing strength at lower pressures.
  • In-vitro studies showed over 90% tannin release within 1 hour.
  • Granule-based tablets demonstrated reduced fracture tendency compared to direct compression.

Conclusions:

  • Wet granulation and direct compression are effective techniques to overcome the poor flowability and compressibility of Terminalia chebula fruit powder.
  • These methods yield robust tablet formulations with desirable compactibility and rapid drug release.
  • The study validates the use of these technologies for developing effective Terminalia chebula dosage forms.