Gastric sarcoidosis: a rare clinical presentation

Area of Science:

• Gastroenterology
• Immunology
• Rare Diseases

Background:

• Gastrointestinal (GI) sarcoidosis is an uncommon manifestation of sarcoidosis.
• Gastric sarcoidosis represents the most frequent form of GI involvement.
• Symptomatic gastric sarcoidosis is exceptionally rare, with limited documented cases.

Purpose of the Study:

• To report a rare case of symptomatic gastric sarcoidosis.
• To illustrate the diagnostic findings and treatment of gastric sarcoidosis.
• To underscore the importance of considering gastric sarcoidosis in patients with relevant symptoms and history.

Main Methods:

• Case report of a 39-year-old Caucasian male presenting with epigastric pain and weight loss.
• Diagnostic evaluation included endoscopic gastric mucosal biopsies.
• Histopathological examination confirmed noncaseating granulomas.

Main Results:

• Histology revealed noncaseating granulomas, confirming gastric sarcoidosis.
• Treatment with oral steroids resulted in symptom alleviation.
• The patient remained recurrence-free for 2 years post-treatment.

Conclusions:

• Gastric sarcoidosis, though rare, should be considered in the differential diagnosis of unexplained GI symptoms.
• Early diagnosis and appropriate treatment, such as corticosteroids, can lead to favorable outcomes.
• This case adds to the literature on symptomatic gastric sarcoidosis and its management.