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Interhypothalamic adhesion in a 9-month-old male with cleft palate
Matthew T Whitehead1, Jacqueline D S Angel2
1Department of Radiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA ; Department of Radiology, Le Bonheur Neuroscience Institute, Le Bonheur Children's Hospital, 50 North Dunlap Street G216, Memphis, TN 38103, USA.
Case Reports in Radiology
|December 26, 2013
Summary
A brain MRI in an infant with congenital anomalies revealed an interhypothalamic adhesion. This finding may represent a mild form of holoprosencephaly, suggesting a spectrum of brain development disorders.
Area of Science:
- Pediatric Radiology
- Neurodevelopmental Disorders
- Congenital Anomalies
Background:
- Infants with multiple congenital anomalies, including cleft lip and palate, require thorough evaluation for intracranial abnormalities.
- Holoprosencephaly is a spectrum of brain malformations with varying severity.
Purpose of the Study:
- To report a case of interhypothalamic adhesion in an infant with congenital anomalies.
- To discuss the potential significance of this finding as a forme fruste of holoprosencephaly.
Main Methods:
- Brain Magnetic Resonance (MR) imaging was performed on a 9-month-old male infant.
- Clinical history of multiple congenital anomalies, including cleft lip and palate, was considered.
Main Results:
- Brain MR imaging identified an interhypothalamic adhesion.
- No other significant intracranial abnormalities were detected.
Conclusions:
- Interhypothalamic adhesion can be an indicator of a mild or incomplete form of holoprosencephaly.
- This finding highlights the importance of neuroimaging in infants with congenital anomalies to detect subtle brain malformations.
