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Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
Published on: March 29, 2024
Expression and prognostic significance of CIP2A in cutaneous malignant melanoma
Feng Shi1, Yayun Ding, Shaoqing Ju
1Department of Dermatology and Venereology, Nantong University , Nantong, Jiangsu , China .
Objective:
We investigated the expression and clinical significance of Cancerous inhibitor of protein phosphatase 2A (CIP2A) in Cutaneous malignant melanoma (CMM).
Methods:
CIP2A expression was analyzed by immunohistochemistry and western blot. We tested the invasion and migration capability of A375 cells with Matrigel invasion assay, Scratch migration assay and Matrigel migration assay after down-regulating CIP2A expression using siRNA.
Results:
CIP2A immunostaining level was correlated with Breslow thickness, Clark's Level and lymphovascular invasion. High-CIP2A expression implied poor survival for patients. Downregulation of CIP2A attenuated metastasis of CMM cells.
Conclusions:
CIP2A may serve as a novel marker to predict the prognosis for CMM patients.
