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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Reproducibility of noncalcified coronary artery plaque burden quantification from coronary CT angiography across

Shane Oberoi1, Felix G Meinel, U Joseph Schoepf

  • 11 Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, Ashley River Tower, Charleston, SC 29425.

AJR. American Journal of Roentgenology
|December 28, 2013
PubMed

Insights

Commercial software for quantifying noncalcified coronary artery plaque volume shows good intraplatform reproducibility but poor interplatform reproducibility. Consistent use of the same software is crucial for serial or comparative assessments of coronary artery disease (CAD).

Area of Science:

  • Cardiovascular Imaging
  • Medical Software Evaluation
  • Quantitative Plaque Analysis

Background:

  • Noncalcified coronary artery plaque burden is a key indicator of coronary artery disease (CAD).
  • Accurate quantification of plaque volume is essential for monitoring disease progression and treatment efficacy.
  • Commercial software platforms are increasingly used for automated plaque quantification from coronary CT angiography (CTA).

Purpose of the Study:

  • To assess the reproducibility of noncalcified coronary artery plaque burden quantification across different commercial analysis platforms.
  • To compare the performance of three distinct software platforms in measuring plaque volume from identical coronary CTA datasets.

Main Methods:

  • 47 patients with noncalcified plaques on coronary CTA were included.
  • Automated plaque volume quantification was performed using three commercial software platforms (1-3).
  • Identical attenuation ranges (0-50 HU for low, 50-130 HU for medium) were applied; data analyzed using Pearson correlation and Bland-Altman analysis.

Main Results:

  • Intraplatform repeat measurements showed statistically insignificant differences (p=0.923).
  • Significant interplatform differences in log plaque volumes were observed, particularly at the low-attenuation threshold (p<0.001).
  • Pearson correlation coefficients between platforms ranged from 0.550 to 0.677, indicating moderate agreement.

Conclusions:

  • Current noncalcified plaque quantification software offers good intraplatform reproducibility but poor interplatform reproducibility.
  • Serial or comparative plaque assessments necessitate the use of the same software platform.
  • Development of industry standards is recommended to ensure reproducible cross-manufacturer assessments.
Abstract

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