Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.1K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.1K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Liver Physiology01:30

Liver Physiology

3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
Liver Histology01:27

Liver Histology

10.7K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
10.7K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

2.7K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.7K
Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: Introduction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: VCA.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: Kidney.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: DOD.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

OPTN/SRTR 2020 Annual Data Report: Heart.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same journal

Comment on "Drug Overdose Mortality Decline and Deceased Donor Transplantation in the United States".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Comment on "Role of social determinants and outcomes of patients with alcohol-associated liver disease referred for early liver transplantation: A multicenter analysis".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo & Uganda.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Donor Acute Kidney Injury Is Not Associated With Inferior Outcomes After Simultaneous Pancreas-Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Human Biopsy-Defined IRI-Selective Reperfusion Signature Prioritizes Reperfusion-Timed MEK Inhibition After DCD Liver Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

14.2K

OPTN/SRTR 2012 Annual Data Report: liver.

W R Kim1, J M Smith, M A Skeans

  • 1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|December 31, 2013
PubMed
Summary
This summary is machine-generated.

Liver transplant in the US is a life-saving procedure. Despite improved graft survival, waiting list times increased for adults, with more removed due to illness.

Keywords:
Liver transplantmodel for end-stage liver diseasewaiting list

More Related Videos

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
09:51

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

2.4K
Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
07:13

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Published on: April 20, 2021

3.8K

Related Experiment Videos

Last Updated: May 4, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

14.2K
Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
09:51

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

2.4K
Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
07:13

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Published on: April 20, 2021

3.8K

Area of Science:

  • Transplantation medicine
  • Hepatology
  • Public health

Background:

  • Liver transplantation is a critical treatment for end-stage liver disease in the US.
  • In 2012, over 6,000 adult liver transplants were performed, with more than 65,000 individuals living with a transplanted liver.
  • The number of adults on the liver transplant waiting list saw a decrease in new registrations.

Purpose of the Study:

  • To analyze trends in liver transplantation in the US in 2012.
  • To examine waiting list dynamics, transplant rates, and graft survival.
  • To assess pediatric and adult liver transplant statistics and outcomes.

Main Methods:

  • Analysis of national liver transplant data from 2012.
  • Comparison of waiting list additions and removals between 2011 and 2012.
  • Evaluation of deceased donor transplant rates and geographical variations.
  • Assessment of graft survival rates, particularly for donation after circulatory death livers.
  • Review of pediatric transplant candidate data and outcomes.

Main Results:

  • The number of new adult candidates on the liver transplant waiting list decreased in 2012.
  • Median waiting time for adult candidates increased, along with removals due to critical illness.
  • The overall deceased donor transplant rate was 42.3 per 100 patient-years, with significant geographical disparities.
  • Graft survival rates continue to improve, especially for livers from donation after circulatory death.
  • Pediatric transplant waiting list additions also decreased, with high 3-year transplant rates and 30-day graft survival.

Conclusions:

  • While liver transplant procedures remain successful, challenges exist with increasing wait times and patient acuity.
  • Improvements in graft survival, particularly with donation after circulatory death, are encouraging.
  • Geographical variations in transplant rates highlight potential access disparities.
  • Pediatric transplant outcomes show positive trends in timely transplantation and short-term graft survival.