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Updated: May 4, 2026

A Murine Model of Carotid Aneurysm Formation
Published on: September 9, 2025
Inflammation and human cerebral aneurysms: current and future treatment prospects
Joseph S Hudson1, Danielle S Hoyne2, David M Hasan3
1University of Iowa, Iowa City IA, USA.
Abstract:
The formation of cerebral aneurysms and their rupture propensity is of immediate clinical importance. Current management includes observation with expectant management, microsurgical clipping and/or endovascular coiling. The surgical options are invasive and are not without increased risk despite the technological advances. Recent human and animal studies have shown that inflammation plays a critical role in aneurysm formation and progression to rupture. Modulating this inflammatory process may prove to be clinically significant. This review will discuss cerebral aneurysm pathogenesis with a focus on current and future research of potential use of pharmaceutical agents that attenuate inflammation in the aneurysm wall leading to decreased risk of aneurysm rupture.
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