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Published on: May 16, 2019
Newer anti-epileptic drugs
Satinder Aneja1, Suvasini Sharma
1Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Childrens Hospital, New Delhi, India. Correspondence to: Dr Satinder Aneja, Director Professor and Head, Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Childrens Hospital, New Delhi, India. drsaneja@gmail.com.
Newer anti-epileptic drugs offer improved epilepsy treatment for children. Oxcarbazepine is effective for partial-onset seizures, while vigabatrin is key for infantile spasms.
Area of Science:
- Pediatric Neurology
- Pharmacology
- Epilepsy Treatment
Background:
- Recent advancements in anti-epileptic drugs (AEDs) aim to enhance epilepsy treatment outcomes.
- This review focuses on the application and efficacy of newer AEDs specifically in pediatric populations.
Purpose of the Study:
- To review the current use of newer anti-epileptic drugs in children.
- To synthesize evidence on indications, efficacy, and adverse effects of these medications in pediatric epilepsy.
Main Methods:
- A comprehensive MEDLINE search (1966-2013) was conducted.
- Keywords included specific newer AEDs and general terms like 'anti-epileptic drugs' and 'children'.
- Various study types were included: reviews, guidelines, RCTs, cohort studies, and case series.
Main Results:
- Oxcarbazepine is effective as initial monotherapy for pediatric partial-onset seizures.
- Vigabatrin is the preferred treatment for infantile spasms linked to tuberous sclerosis.
- Lamotrigine, levetiracetam, and lacosamide show promise as add-on therapies for partial seizures.
Conclusions:
- Oxcarbazepine is established for initial monotherapy in pediatric partial-onset seizures.
- Vigabatrin is the drug of choice for infantile spasms in tuberous sclerosis.
- Lamotrigine, levetiracetam, and lacosamide are beneficial add-on or monotherapy options for specific pediatric epilepsy syndromes.
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