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Downregulation of CD4+LAP+ and CD4+CD25+ regulatory T cells in acute coronary syndromes

Ying-zhong Lin1, Shan-he Lu1, Zheng-de Lu1

  • 1Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Mediators of Inflammation
|January 4, 2014
PubMed

Insights

Regulatory T (Treg) cells, including CD4+LAP+ Tregs, are decreased in acute coronary syndromes (ACS). This reduction in regulatory T cells and associated cytokines may contribute to ACS onset.

Area of Science:

  • Immunology
  • Cardiology
  • Molecular Biology

Background:

  • Regulatory T (Treg) cells are crucial in atherosclerosis and acute coronary syndromes (ACS).
  • CD4+LAP+ Treg cells, a novel subset, show promise in ameliorating atherosclerosis and are present in humans.
  • The study investigates the role of CD4+LAP+ Treg cells in the onset of ACS.

Purpose of the Study:

  • To determine the involvement of CD4+LAP+ Treg cells in the onset of acute coronary syndromes (ACS).
  • To compare frequencies of CD4+LAP+ and CD4+CD25+ Treg cells in ACS patients versus controls.

Main Methods:

  • Flow cytometry was used to quantify CD4+LAP+ and CD4+CD25+ Treg cell frequencies.
  • ELISA measured plasma levels of IL-10 and TGF-β1.
  • Study included patients with stable angina (SA), non-ST-elevation ACS (NSTEACS), ST-elevation myocardial infarction (STEMI), and healthy controls.

Main Results:

  • Patients with ACS exhibited significantly lower frequencies of CD4+LAP+ and CD4+CD25+ Treg cells compared to SA and control groups.
  • Reduced levels of IL-10 and TGF-β1 were observed in ACS patients.
  • A significant decrease in regulatory T cell populations and key cytokines was noted in ACS.

Conclusions:

  • A diminished frequency of CD4+LAP+ and CD4+CD25+ Treg cells may be implicated in the pathogenesis of ACS.
  • The findings suggest a potential role for these Treg subsets in ACS development.
Abstract

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