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Updated: May 4, 2026
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Cationic Eudragit® polymers as excipients for microparticles prepared by solvent evaporation method.
Summary
Eudragit® RS and Eudragit® E 100 successfully formed mirtazapine and tramadol hydrochloride microparticles. Eudragit® RS demonstrated superior performance in encapsulation, drug loading, and particle size for drug delivery systems.
Area of Science:
- Pharmaceutical Technology
- Polymer Science
Background:
- Cationic acrylic polymers are widely used in drug delivery.
- Microparticle preparation requires careful selection of polymers and drugs.
Purpose of the Study:
- To evaluate Eudragit® RL, RS, and E 100 for microparticle preparation.
- To encapsulate drugs with extreme solubility differences (mirtazapine and tramadol hydrochloride).
Main Methods:
- Solvent evaporation method for microparticle preparation.
- Analysis using optical microscopy, drug content assay, and dissolution testing.
Main Results:
- Eudragit® RS and E 100 formed spherical microparticles; Eudragit® RL did not.
- Mirtazapine exhibited sustained release, while tramadol hydrochloride showed immediate release.
- Eudragit® RS outperformed Eudragit® E 100 in encapsulation efficiency, drug loading, and mean particle size.
Conclusions:
- Eudragit® RS and E 100 are suitable for microparticle formulation.
- Polymer choice significantly impacts drug release profiles and microparticle characteristics.
- Eudragit® RS is a preferred polymer for developing microparticulate drug delivery systems with enhanced properties.
