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Updated: May 4, 2026

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Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
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Traumatic coagulopathy--part 2: Resuscitative strategies
1Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.
Summary
Hemorrhagic shock and acute traumatic coagulopathy (ATC) require prompt treatment. Damage control resuscitation, including antifibrinolytics and viscoelastic tests, improves survival in trauma patients.
Area of Science:
- Veterinary Emergency and Critical Care
- Trauma Resuscitation
- Hemorrhagic Shock Management
Background:
- Hemorrhagic shock is a leading cause of preventable death in trauma.
- Traditional crystalloid resuscitation may be detrimental in uncontrolled hemorrhage.
- Optimal resuscitation strategies for trauma are still being defined, especially in veterinary medicine.
Purpose of the Study:
- To discuss current resuscitative strategies for trauma-induced hemorrhagic shock.
- To review approaches for managing acute traumatic coagulopathy (ATC).
- To highlight the need for evidence-based veterinary protocols.
Main Methods:
- Damage control resuscitation (DCR) principles for hemorrhage control, acidosis, and hypothermia.
- Management of ATC, including the role of antifibrinolytics (e.g., tranexamic acid).
- Utilizing viscoelastic tests and scoring systems for early ATC detection and transfusion guidance.
Main Results:
- Hemorrhage is a major cause of trauma mortality.
- Damage control resuscitation improves survival by controlling hemorrhage and coagulopathy.
- Antifibrinolytics may benefit early post-trauma care.
Conclusions:
- Survivability hinges on rapid hemostasis, early coagulopathy management, and volume restoration.
- Early DCR can mitigate post-traumatic coagulopathy, acidosis, and hypothermia.
- Veterinary medicine often extrapolates from human data for trauma resuscitation.
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