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Subclinical cardiovascular disease in plaque psoriasis: association or causal link?

Sameer Shaharyar1, Haider Warraich2, John W McEvoy3

  • 1Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami Beach, FL, USA.

Atherosclerosis
|January 10, 2014
PubMed

Insights

Psoriasis patients show increased signs of early cardiovascular disease, including arterial issues and endothelial dysfunction. Early screening for cardiovascular disease risk is recommended for patients with severe or long-standing psoriasis.

Area of Science:

  • Dermatology and Cardiology
  • Investigating the link between skin disease and cardiovascular health

Background:

  • Psoriasis patients face a higher risk of cardiovascular events.
  • A direct causal link between psoriasis and cardiovascular disease remains unproven.
  • This study reviews evidence on endothelial dysfunction and subclinical atherosclerosis in psoriasis.

Purpose of the Study:

  • To systematically review existing data on endothelial dysfunction in psoriasis patients.
  • To assess subclinical atherosclerosis markers in individuals with plaque psoriasis.

Main Methods:

  • A systematic literature search was conducted using the Medline database and Ovid SP.
  • The search included studies published up to November 2012.
  • Twelve studies met the inclusion criteria from 529 initial articles.

Main Results:

  • Two studies (17%) found increased coronary artery calcification (CAC) in psoriasis patients.
  • Six studies (50%) indicated increased carotid intima-media thickness (CIMT).
  • Five studies (42%) on flow-mediated dilation (FMD) showed decreased FMD in three cases, while others noted reduced coronary flow reserve and increased arterial stiffness.

Conclusions:

  • Psoriasis is associated with a higher burden of subclinical atherosclerosis and endothelial dysfunction.
  • Patients with severe or long-duration psoriasis warrant targeted cardiovascular disease screening.
  • Early detection and risk reduction strategies are crucial for managing cardiovascular risks in psoriasis patients.
Abstract

Keywords:
AtherosclerosisCarotid intima–media thicknessCoronary artery calciumPrimary preventionPsoriasisSub-endothelial dysfunction

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