Related Experiment Video

Updated: May 4, 2026

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

13.9K

The effects of gout on left atrial volume remodelling: a prospective echocardiographic study

Kuo-Li Pan1, Jing-Chi Lin, Chun-Liang Lin

  • 1Division of Cardiology, Chang Gung Memorial Hospital, No. 6, West Chia-Pu Road, Putz, Chiayi Hsien, Taiwan 613, Republic of China. pankuoli64@gmail.com.

Rheumatology (Oxford, England)
|January 11, 2014
PubMed

Insights

Gout significantly impacts heart function, causing left ventricular diastolic dysfunction and left atrial enlargement. Higher left atrial volume index predicts tophi development in gout patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Echocardiography

Background:

  • Gout is a metabolic disorder associated with cardiovascular complications.
  • Left ventricular (LV) diastolic dysfunction and left atrial (LA) enlargement are indicators of cardiac remodeling.

Purpose of the Study:

  • To investigate the impact of gout on LV diastolic function and LA volume (LAV).
  • To assess the relationship between gout severity and cardiac structural changes.

Main Methods:

  • 173 patients were categorized into control, asymptomatic hyperuricaemia, gouty arthritis without tophi, and gouty tophi groups.
  • Comprehensive Doppler echocardiography was performed to evaluate LV and LA parameters.
  • Statistical analysis, including binary logistic regression, was used to identify predictors.

Main Results:

  • The ratio of transmitral and myocardial peak early diastolic velocities (E/e') and LAV index (LAVi) progressively increased with gout severity.
  • The gouty tophi group exhibited significantly higher E/e' and larger LAVi compared to the control group.
  • Maximal LAVi was identified as an independent predictor for tophi development in gout patients.

Conclusions:

  • Gout severity significantly influences LV diastolic dysfunction and LA enlargement.
  • Elevated maximal LAVi may predict tophi development and adverse cardiovascular events in gout patients.
  • LA and LV remodeling are key factors in gout-related cardiovascular complications.
Abstract

Keywords:
diastolic dysfunctiongoutleft atrial volumeuric acid

More Related Videos

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

1.4K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.7K

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
598
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.6K
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
964