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Irrelevant IgE binding to cellulose discs in RAST.
International Archives of Allergy and Applied Immunology
|January 1, 1987
Summary
Two human sera exhibited irrelevant immunoglobulin E (IgE) binding to allergens on cellulose discs, but not on agarose beads. This non-specific IgE binding can be identified using human serum albumin-coated discs.
Area of Science:
- Allergy diagnostics
- Immunology
- Biochemical assays
Background:
- Non-specific immunoglobulin E (IgE) binding can interfere with accurate allergy testing.
- Cellulose discs are a common solid-phase carrier for allergens in immunoassays.