Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Degradation, swelling, and drug release behavior of injectable ETTMP/PEGDA hydrogels.

Biomedical materials (Bristol, England)·2025

Same author

Factors That Influence Base-Catalyzed Thiol-Ene Hydrogel Synthesis.

Gels (Basel, Switzerland)·2023

Same author

Water Diffusion and Uptake in Injectable ETTMP/PEGDA Hydrogels.

The journal of physical chemistry. B·2023

Same author

A two-region transport model for interpreting T<sub>1</sub>-T<sub>2</sub> measurements in complex systems.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2019

Same author

Flow velocity maps measured by nuclear magnetic resonance in medical intravenous catheter needleless connectors.

Journal of pharmaceutical and biomedical analysis·2018

Same author

Quantifying NMR relaxation correlation and exchange in articular cartilage with time domain analysis.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2018

Search research articles

Related Experiment Video

Updated: May 4, 2026

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

A microfluidic method to measure small molecule diffusion in hydrogels.

Stephanie M Evans¹, Andrew L Litzenberger¹, Anne E Ellenberger¹

¹Department of Chemical Engineering, Bucknell University, Lewisburg, PA 17837, USA.

Materials Science & Engineering. C, Materials for Biological Applications

|January 14, 2014

Summary

This study demonstrates how microfluidic devices can accurately track drug release from hydrogels, revealing unexpected diffusion behaviors crucial for designing effective drug delivery systems.

Keywords:

Controlled drug delivery Diffusion Hydrogels Microfluidics NMR PEG

More Related Videos

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

Related Experiment Videos

Last Updated: May 4, 2026

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

Area of Science:

Biomaterials Science
Drug Delivery
Microfluidics

Background:

Drug release from biomaterials is critical for effective drug delivery.
Understanding solute diffusion in hydrogels is essential for designing drug delivery devices.
Current methods may not fully capture complex diffusion behaviors.

Purpose of the Study:

To simulate and analyze drug release from hydrogels using a microfluidic device.
To determine diffusion coefficients of model drugs in poly(ethylene glycol) diacrylate (PEG-DA) hydrogels.
To compare the efficacy of different analytical methods in characterizing solute diffusion.

Main Methods:

Utilized a microfluidic device with a solute-loaded hydrogel channel.
Employed in-situ hydrogel optical analysis, effluent characterization, and Nuclear Magnetic Resonance (NMR) spectroscopy.
Investigated diffusion of methylene blue, sulforhodamine 101, and acid blue 22 in PEG-DA hydrogels.

Main Results:

Diffusion coefficients for methylene blue and sulforhodamine 101 in PEG-DA were consistent across NMR, optical, and effluent methods.
Acid blue 22 exhibited anomalous diffusion behavior not detected by all methods.
The microfluidic method uniquely identified the aberrant release of acid blue 22.

Conclusions:

Combining NMR, optical, and effluent methods provides comprehensive insight into hydrogel molecular diffusion.
Microfluidic techniques are vital for detecting non-ideal solute release, essential for drug delivery device design.
A multi-level analysis, from molecular to device scale, is crucial for understanding drug elution.