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The pathophysiological role of dendritic cell subsets in psoriasis
Tae-Gyun Kim1, Dae Suk Kim2, Hyoung-Pyo Kim3
1Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.
BMB Reports
|January 14, 2014
Summary
Psoriasis involves immune cells like dendritic cells and T cells. Targeting dendritic cell cytokines offers improved psoriasis treatments, highlighting their key role in the disease.
Area of Science:
- Immunodermatology
- Cellular immunology
- Inflammatory skin diseases
Background:
- Psoriasis is a chronic immune-mediated skin disease.
- Psoriatic lesions show increased cytokine-producing dendritic cells and T cells.
- Dendritic cell subsets play critical roles in psoriasis initiation and maintenance.
Purpose of the Study:
- To review dendritic cell subsets in human skin.
- To discuss their pathophysiological involvement in psoriasis.
- To highlight novel therapeutic targets.
Main Methods:
- Review of mouse-oriented studies.
- Analysis of patient-oriented studies.
- Summary of current literature on dendritic cells in psoriasis.
Main Results:
- Dendritic cells are crucial in psoriasis pathogenesis.
- Specific dendritic cell subsets are implicated in disease initiation and maintenance.
- Targeting lesional dendritic cell-derived cytokines yields significant clinical improvement.
Conclusions:
- Dendritic cells are central to psoriasis pathogenesis.
- Targeted therapies against dendritic cell cytokines represent a promising treatment strategy.
- Further research into dendritic cell subsets can advance psoriasis management.
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