Related Experiment Video

Updated: May 4, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K

Factors associated with early platelet activation in obese children

Anel Gómez García1, Guillermina García Núñez2, Martha Eva Viveros Sandoval3

  • 1Biomedical Research Center of Michoacán, Mexican Institute of Social Security, Morelia, Michoacán, México. anel_gomez04@yahoo.com.mx anel.gomez@imss.gob.mx.

Clinical Medicine & Research
|January 14, 2014
PubMed

Insights

Obese children show increased platelet activation, linked to higher levels of leptin, von Willebrand Factor (vWF), uric acid (UA), and lower high-density lipoprotein (HDL). These factors may indicate early cardiovascular risk in pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Hematology
  • Cardiovascular Research

Background:

  • Childhood obesity is a growing global health concern.
  • Obesity is associated with increased risk of cardiovascular disease.
  • Platelet activation plays a role in atherothrombosis.

Purpose of the Study:

  • To investigate factors associated with platelet activation in obese children.
  • To identify predictors of platelet activation in pediatric obesity.

Main Methods:

  • Cross-sectional study involving 79 obese and 64 non-obese children (ages 5-10).
  • Assessed platelet activation via soluble P-selectin (sP-selectin).
  • Measured leptin, uric acid (UA), von Willebrand Factor (vWF), PAI-1, lipid profile, and glucose.

Main Results:

  • Obese children had higher plasma sP-selectin, leptin, PAI-1, and vWF.
  • Leptin, vWF, UA, and HDL were associated with platelet activation.
  • Leptin, vWF, UA, and HDL were the best predictors of platelet activation, adjusted for age and sex.

Conclusions:

  • Obese children exhibit heightened risk for early platelet activation.
  • Leptin, vWF, UA, and HDL are key factors linked to platelet activation in obese children.
  • Further research is needed to elucidate mechanisms and long-term cardiovascular implications.
Abstract

Keywords:
ChildrenEndothelial activationLeptinObesityUric acid

More Related Videos

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies07:06

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

1.2K
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

7.1K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.2K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
324
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
440
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
7.1K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
368