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Association between insulin resistance and bone mass in men
Doosup Shin1, Soyeun Kim, Kyae Hyung Kim
1Jangseong Public Health Center (D.S.), Jangseong, 515-800 South Korea; Department of Family Medicine (S.K.), Korea Cancer Center Hospital, Seoul 139-240, South Korea; Department of Family Medicine (K.H.K., S.M.P.) and Department of Biomedical Sciences (S.M.P.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul 110-744, South Korea; and Department of Family Medicine (K.L.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do 463-707, South Korea.
Insulin resistance and high fasting insulin levels are linked to lower bone mass in Korean men. This association varies with the degree of insulin resistance, suggesting complex interactions affecting bone health.
Area of Science:
- Endocrinology
- Bone Metabolism
- Public Health
Background:
- The relationship between insulin resistance and bone mass remains unclear.
- Understanding this association is crucial for metabolic and bone health.
Purpose of the Study:
- To investigate the association between insulin resistance and bone mass in a representative sample of Korean men.
- To explore how insulin resistance impacts bone mineral density (BMD).
Main Methods:
- Cross-sectional survey of 3113 Korean men (aged ≥20 years) from 2008-2009.
- Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry.
- Insulin resistance assessed using homeostasis model assessment-estimated insulin resistance (HOMA-IR).
Main Results:
- Decreased BMD observed with increasing HOMA-IR and fasting insulin levels.
- Higher HOMA-IR or insulin levels correlated with increased odds of osteopenia/osteoporosis.
- The association between fasting insulin and BMD shifted from positive to inverse as insulin resistance worsened.
Conclusions:
- Insulin resistance and elevated fasting insulin levels are inversely associated with bone mass in Korean men.
- The findings highlight a complex interplay between metabolic and skeletal health.
- Further research is needed to elucidate the underlying mechanisms of this association.
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