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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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IL-17: a key player in the P. acnes inflammatory cascade?
Diane M Thiboutot1, Alison M Layton2, E Anne Eady2
1Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
The Journal of Investigative Dermatology
|January 16, 2014
Summary
Propionibacterium acnes triggers interleukin-17 (IL-17) expression in immune cells. Researchers found IL-17 producing cells within acne lesions, suggesting a role for IL-17 in this inflammatory skin condition.
Area of Science:
- Dermatology
- Immunology
- Microbiology
Background:
- Acne vulgaris is a common inflammatory skin disease.
- Microbial and host interactions are crucial in acne pathogenesis.
- Interleukin-17 (IL-17) is a pro-inflammatory cytokine implicated in various inflammatory conditions.
Purpose of the Study:
- To investigate the role of Propionibacterium acnes in inducing IL-17 expression.
- To examine the presence of IL-17 producing cells in acne lesions.
Main Methods:
- Peripheral blood mononuclear cells (PBMCs) were stimulated with Propionibacterium acnes.
- Immunohistochemistry was used to detect IL-17+ cells in comedonal biopsies.
Main Results:
- Propionibacterium acnes induced IL-17 expression in PBMCs.
- IL-17+ cells were identified in the perifollicular infiltrate of comedones.
Conclusions:
- Propionibacterium acnes may contribute to acne inflammation by inducing IL-17.
- Further research is required to establish the clinical significance of IL-17 in acne pathogenesis.
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