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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for ATM, RAD9 and BRCA1.

G Zhou1, L B Smilenov1, H B Lieberman1

  • 1Center for Radiological Research, Columbia University Medical Center, New York, NY10032, USA.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 17, 2014
PubMed
Summary

Heterozygosity for multiple DNA repair genes, such as ATM and RAD9 or ATM and BRCA1, increases cancer risk and radiosensitivity. This identifies a radiosensitive subpopulation with implications for radiation exposure and cancer development.

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