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[Potentials for the correction of endothelial and erectile dysfunction in patients after coronary artery bypass

E V Pomeshkin, A I Neĭmark, S A Pomeshkina

    Urologiia (Moscow, Russia : 1999)
    |January 21, 2014
    PubMed

    Insights

    Impaza improved erectile function and endothelial function in men after coronary artery bypass grafting (CABG). However, effects were short-term, suggesting longer use may be needed for sustained benefits in cardiovascular disease patients.

    Area of Science:

    • Cardiovascular Medicine
    • Urology
    • Pharmacology

    Background:

    • Coronary artery bypass grafting (CABG) can impact endothelial and erectile function.
    • Erectile dysfunction (ED) is a common concern in patients with coronary artery disease (CAD).
    • Nitric oxide (NO) plays a crucial role in endothelial and erectile function.

    Purpose of the Study:

    • To evaluate the effect of the NO-synthase inducer, impaza, on endothelial and erectile function in patients undergoing CABG.
    • To assess the impact of impaza on nitric oxide (NO) and endothelin-1 (ET-1) levels.
    • To compare the efficacy of impaza plus standard rehabilitation versus standard rehabilitation alone.

    Main Methods:

    • A study involving 127 men with stable CAD planned for CABG.
    • Assessment of the International Index of Erectile Function (IIEF) score, blood lipid levels, nocturnal penile tumescence, and postcompression tests.
    • Measurement of plasma NO and ET-1 levels to assess endothelial function.
    • A 24-week treatment period with impaza (1 tablet/day) in the study group versus a standard rehabilitation program in the control group.

    Main Results:

    • Impaza use for 24 weeks improved erectile function in patients with ED undergoing CABG.
    • A year post-surgery, erectile function deteriorated, indicating a short-term effect of impaza.
    • Six months post-CABG, impaza recipients showed improved endothelial function markers (NO, ET-1) compared to controls, but differences vanished one year later.

    Conclusions:

    • Impaza demonstrates a short-term positive influence on erectile function and endothelial parameters in CAD patients post-myocardial revascularization.
    • The transient nature of impaza's effects suggests that prolonged administration may be necessary for sustained benefits.
    • Restorative treatment with impaza positively affects NO and ET-1 levels, enhancing vasodilator and reducing vasoconstrictor properties of the endothelium.

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