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[Biological properties of opportunistic microorganisms--agents of acute intestinal infections]

N G Malysh, V N Golubnichaia, N D Chemich

    Mikrobiolohichnyi Zhurnal (Kiev, Ukraine : 1993)
    |January 24, 2014
    PubMed

    Insights

    Conditionally pathogenic bacteria like Klebsiella pneumoniae and Staphylococcus aureus are key in acute intestinal infections. These bacteria exhibit phenotypic heterogeneity and possess virulence factors enabling adhesion and persistence.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Public Health

    Background:

    • Acute intestinal infections pose a significant public health challenge.
    • The role of conditionally pathogenic bacteria in these infections requires further investigation.
    • Geographical variations in bacterial etiology are important for regional health strategies.

    Purpose of the Study:

    • To investigate the etiological significance of conditionally pathogenic bacteria in acute intestinal infections within the Sumy region.
    • To characterize the phenotypic heterogeneity of isolated bacterial strains.
    • To identify specific virulence factors contributing to bacterial pathogenicity.

    Main Methods:

    • Isolation and identification of bacterial strains from patients with acute intestinal infections.
    • Phenotypic characterization of bacterial isolates.
    • Detection of pathogenicity factors, including anti-interferon and anticomplement activity.

    Main Results:

    • Klebsiella pneumoniae, Staphylococcus aureus, and Enterobacter cloacae were identified as etiological agents.
    • Significant phenotypic heterogeneity was observed among the studied bacterial strains.
    • Pathogenicity factors, crucial for adhesion and persistence, were identified in a high percentage of K. pneumoniae (85.0 +/- 5.6%), E. cloacae (30.0 +/- 7.2%), and S. Aureus (20.0 +/- 5.6%) strains.

    Conclusions:

    • Conditionally pathogenic bacteria play a crucial role in acute intestinal infections in the Sumy region.
    • Phenotypic heterogeneity influences the pathogenicity of these bacteria.
    • The identified virulence factors (anti-interferon and anticomplement activity) are critical for bacterial survival and infection progression.

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