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Heart Failure III: Clinical Manifestations

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...

Heart Failure IV: Classification and Diagnostic Evaluation

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...

Heart Failure I: Introduction

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Heart Failure VII: Nursing Interventions

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

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Updated: May 3, 2026

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

Heart failure highlights in 2012-2013.

Licette C Y Liu¹, Kevin Damman, Eric Lipsic

¹The Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

European Journal of Heart Failure

|January 28, 2014

Summary

This summary is machine-generated.

Recent advances in heart failure management offer new insights into its pathophysiology, diagnosis, and treatment. Key discoveries and clinical trials from 2012-2013 are reviewed for improved patient care.

Keywords:

Assist devices Atrial fibrillation Biomarkers CRT Co-morbidities Heart failure Highlights 2012/13 Interventional treatment Pathophysiology Pharmacological therapy

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

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Last Updated: May 3, 2026

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Area of Science:

Cardiology
Heart Failure Research

Background:

Heart failure represents a major global cardiovascular health challenge.
The European Journal of Heart Failure actively promotes advancements in this field.

Purpose of the Study:

To review significant scientific discoveries and clinical trials in heart failure published in 2012-2013.
To synthesize novel insights into heart failure pathophysiology, diagnosis, and treatment.

Main Methods:

Literature review of key publications from 2012-2013.
Discussion of research across various heart failure domains.

Main Results:

Identification of pioneering scientific discoveries and paradigm-shifting clinical trials.
Synthesis of novel insights into heart failure pathophysiology, diagnosis, and treatment.

Conclusions:

The period of 2012-2013 yielded crucial advancements in understanding and managing heart failure.
Comprehensive review covers pathophysiology, comorbidities, arrhythmias, biomarkers, clinical trials, and device therapy, including left ventricular assist devices.