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Updated: May 3, 2026

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
Published on: September 2, 2020
Reconstitution of OmpF membrane protein on bended lipid bilayers: perforated hexagonal mesophases
Alexandru Zabara1, Renata Negrini, Patric Baumann
1Food & Soft Material Science, Institute of Food Nutrition and Health, ETH Zurich, Schmelzbergstrasse 9, LFO E23, 8092, Zurich, Switzerland. raffaele.mezzenga@hest.ethz.ch.
Abstract:
Membrane proteins have been reconstituted on lipid bilayers with zero mean-curvature (cubic phases or vesicles). Here we show that reconstitution of pore-forming membrane proteins can also occur on highly curved lipidic bilayers of reverse hexagonal mesophases, for which the mean-curvature is significantly different from zero. We further show that the membrane protein provides unique topological interconnectivities between the aqueous nanochannels, significantly enhancing mesophase transport properties.
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