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Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent
Chika Taniguchi1, Yohei Kawabata, Koichi Wada
1University of Shizuoka, School of Pharmaceutical Sciences, Department of Pharmacokinetics and Pharmacodynamics , 52-1 Yada, Suruga-ku, Shizuoka 422-8526 , Japan +81 54 264 5633 ; +81 54 264 5635 ; onoue@u-shizuoka-ken.ac.jp.
Expert Opinion on Drug Delivery
|January 30, 2014
Summary
Modifying the pH of drug formulations can improve the oral absorption of medications with pH-dependent solubility. This pH-modification approach enhances drug dissolution, potentially leading to better therapeutic efficacy.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Oral absorption and drug efficacy for pH-dependent solubility drugs are affected by gastrointestinal tract conditions.
- Poor oral absorption can limit the effectiveness of certain medications.
- Formulation pH modification offers a potential strategy to enhance oral absorption.
Purpose of the Study:
- To review the pH-modifier approach for drug formulations.
- To analyze microenvironmental pH strategies in formulation design.
- To present examples of pH-modification technology in solid dosage forms.
Main Methods:
- Literature and patent review of pH-modification technology.
- Analysis of microenvironmental pH control in formulations.
- Examination of pH-modifying excipients in solid dosage forms.
Main Results:
- Dissolving pH-modifying excipients alters microenvironmental pH.
- Modulated microenvironmental pH can improve dissolution of pH-dependent solubility drugs.
- Key factors for improved dissolution include modulated pH level and duration.
Conclusions:
- pH-modification of formulations can enhance drug dissolution and oral absorption.
- Measuring microenvironmental pH and pH-modifier release aids formulation optimization.
- This approach offers theoretical insights for selecting pH modifiers and optimizing drug delivery.
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