[Stress and metabolic regulation].

Area of Science:

• Endocrinology
• Immunology
• Metabolic Science

Background:

• Stress triggers systemic reactions via neuroendocrine-immune network activation.
• Evidence indicates a strong influence of this network on metabolism under stress.
• Metabolic effects extend beyond glucose, fat, and protein to include trace elements.

Purpose of the Study:

• To elucidate the comprehensive effects of stress on the body's metabolic processes.
• To highlight the role of the neuroendocrine-immune network in stress-induced metabolic changes.
• To underscore the link between sustained stress and metabolic disease development.

Main Methods:

• Review of current scientific literature on stress, neuroendocrine-immune interactions, and metabolism.
• Analysis of studies investigating metabolic alterations under various stress conditions.
• Correlation of sustained stress impacts with disease pathogenesis.

Main Results:

• Stress profoundly affects glucose, fat, and protein metabolism.
• The neuroendocrine-immune network plays a critical role in mediating these metabolic changes.
• Trace element metabolism is also significantly regulated by stress.
• Sustained high-load stress can exceed the body's compensatory mechanisms.

Conclusions:

• The neuroendocrine-immune network's activation during stress has far-reaching metabolic consequences.
• Disruption of metabolic homeostasis by chronic stress contributes to diseases like diabetes and atherosclerosis.
• Understanding these mechanisms is crucial for developing therapeutic strategies against stress-related metabolic disorders.