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Updated: May 3, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
[Stress and metabolic regulation]
Xin-Xing Wang1, Ling-Jia Qian1
1Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Abstract:
The stress is generated in response to changes in internal and external environment of the body is characterized by systemic reactions to neuroendocrine activation of the immune network. More and more evidence suggests that highly activated under stress conditions neuroendocrine immune network will have a strong and sustained influence on the body's metabolism. The effect of stress on the metabolism is not only confined to the glucose metabolism, fat metabolism and protein metabolism, and important role in regulating the metabolism of trace elements. Sustained high-load stress on the metabolism of the negative impact beyond the body's compensatory capacity will lead to a disease such as diabetes, atherosclerosis and secondary diseases.
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