Related Experiment Video

Updated: May 3, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

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MiRNAs in human cancers: the diagnostic and therapeutic implications

Qiong Wu, Zhiping Yang, Yongquan Shi

  • 1127 West Changle Road, Xi'an 710032, China. fandaim@fmmu.edu.cn.

Current Pharmaceutical Design
|February 1, 2014
PubMed

Insights

MicroRNAs (miRNAs) offer promising cancer treatment strategies, addressing limitations of current therapies. This review explores miRNA applications, delivery methods, and combination therapies for improved cancer care.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer treatments like chemotherapy and radiotherapy face challenges including drug resistance and toxicity.
  • MicroRNAs (miRNAs) are key regulators of gene expression with significant roles in cancer development.
  • There is a need for more effective cancer treatment approaches.

Purpose of the Study:

  • To review the clinical implications of microRNAs in cancer.
  • To discuss diagnostic and prognostic values of miRNAs.
  • To explore miRNA-based therapeutic strategies and delivery methods.

Main Methods:

  • Literature review of miRNA biogenesis, biological functions, and roles in cancer.
  • Analysis of diagnostic and prognostic applications of miRNAs.
  • Examination of pre-clinical models and clinical trials involving miRNAs.
  • Review of miRNA delivery systems and combination therapies.

Main Results:

  • MicroRNAs demonstrate significant potential in cancer diagnosis and prognosis.
  • Various miRNA delivery methods are being developed to overcome therapeutic challenges.
  • Combinational therapy involving miRNAs shows promise for enhanced anti-cancer effects.

Conclusions:

  • MicroRNAs represent a promising frontier in targeted cancer therapy.
  • Further research into miRNA delivery and combination strategies is crucial for clinical translation.
  • MicroRNA-based approaches could overcome current limitations in cancer treatment.

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