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Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

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Epithelial-to-Mesenchymal Transition: Liaison between Cancer Metastasis and Drug Resistance

Feng Du1, Hao Liu1, Yuanyuan Lu1

  • 1State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

Critical Reviews in Oncogenesis
|April 2, 2018
PubMed

Insights

Epithelial-mesenchymal transition (EMT) links cancer metastasis and drug resistance. This review explores EMT

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Metastasis and drug resistance are primary drivers of cancer mortality.
  • Tumor cell dissemination and metastasis are linked to poor drug responses.
  • Metastatic cells often exhibit increased drug resistance.

Purpose of the Study:

  • To review recent advances in understanding tumor metastasis and drug resistance.
  • To focus on the association between epithelial-mesenchymal transition (EMT), metastasis, and drug resistance.
  • To elucidate the intrinsic links between EMT, metastasis, and drug resistance in various cancers.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of molecular mechanisms regulating EMT.
  • Discussion of EMT's role in modulating metastasis and drug resistance.

Main Results:

  • EMT plays a critical role in both cancer metastasis and drug resistance.
  • EMT is intrinsically linked to metastasis and drug resistance.
  • Molecular mechanisms and pathways regulating EMT are crucial.

Conclusions:

  • EMT is a key factor connecting cancer metastasis and drug resistance.
  • Understanding EMT's role is vital for developing effective cancer therapies.
  • Further research into the intrinsic links of EMT is warranted across diverse cancer types.

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