Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.5K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.5K
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

1.3K
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
1.3K
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

53
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
53
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

1.5K
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.5K
Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of infectious morbidity due to BTK inhibitors in indolent B-cell lymphomas: latest research findings and systematic analysis.

Expert opinion on pharmacotherapy·2024
Same author

Validation of bladder health scales and function indices for women's research.

American journal of obstetrics and gynecology·2023
Same author

Erratum for Stapleton et al., "Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review".

Antimicrobial agents and chemotherapy·2022
Same author

Survey of lower urinary tract symptoms in United States women using the new lower urinary tract dysfunction research Network-Symptom Index 29 (LURN-SI-29) and a national research registry.

Neurourology and urodynamics·2022
Same author

Non-invasive bladder function measures in healthy, asymptomatic female children and adolescents: A systematic review and meta-analysis.

Journal of pediatric urology·2021
Same author

Robust mosaicking of maize fields from aerial imagery.

Applications in plant sciences·2020

Related Experiment Video

Updated: May 3, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

20.2K

Urinary tract infection pathogenesis: host factors.

Ann E Stapleton1

  • 1Division of Allergy and Infectious Diseases, Medicine, Institute of Translational Health Sciences, University of Washington, Box 356423, Room BB1233, 1959 Northeast Pacific Street, Seattle, WA 98195, USA; Clinical Research Center, Institute of Translational Health Sciences, University of Washington, 7 South UWMC, Box 356178, 1959 Northeast Pacific Street, Seattle, WA 98195, USA.

Infectious Disease Clinics of North America
|February 4, 2014
PubMed
Summary

Urinary tract infection (UTI) pathogenesis involves modifiable factors like behavior and nonmodifiable factors such as genetics. Understanding these host factors can guide future UTI prevention and treatment strategies.

Keywords:
Estrogen statusFemale genderModifiable host factorsNonmodifiable host factorsSexual intercourseUrogenital microbiota

More Related Videos

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

16.6K
Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

36.2K

Related Experiment Videos

Last Updated: May 3, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

20.2K
Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

16.6K
Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

36.2K

Area of Science:

  • Urology
  • Infectious Diseases
  • Host-Pathogen Interactions

Background:

  • Urinary tract infections (UTIs) are common, with pathogenesis influenced by host factors.
  • Host factors are categorized as modifiable (behaviors, anatomical/functional issues) or nonmodifiable (gender, genetics).
  • Understanding host factors is crucial for developing effective UTI management strategies.

Purpose of the Study:

  • To review host factors influencing urinary tract infection (UTI) pathogenesis.
  • To differentiate between modifiable and nonmodifiable host factors in UTI development.
  • To explore the potential clinical utility of understanding host-associated genetic influences on UTI.

Main Methods:

  • Literature review of host factors in UTI pathogenesis.
  • Categorization of host factors into modifiable and nonmodifiable groups.
  • Discussion of the implications of genetic associations for UTI prediction and treatment.

Main Results:

  • Modifiable host factors include behaviors and urinary tract abnormalities, offering targets for intervention.
  • Nonmodifiable host factors, such as gender and genetic predispositions, present challenges but hold future potential.
  • Genetic associations with UTI are increasingly recognized, suggesting predictive value.

Conclusions:

  • Host factors play a significant role in UTI pathogenesis, with both behavioral and intrinsic elements.
  • While modifiable factors can be addressed through lifestyle changes or treatment, nonmodifiable factors require further research.
  • Genetic insights into UTI susceptibility may pave the way for personalized predictive and therapeutic approaches in the future.