Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

189
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
189
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81
Incomplete Dominance01:43

Incomplete Dominance

19.0K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
19.0K
ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

16.0K
In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
16.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

14.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.6K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.8K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the gap: Multi-omic Insights into Exercise Responses in Post-Menopausal Women.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
Same author

Epigenetic Modulation of Exercise Adaptation: The Role of Dietary Supplementation in Athletic Performance.

Genes·2026
Same author

Meta-analysis of DNA methylation aging signatures in 17 human tissues.

Nature aging·2026
Same author

CpG Atlas: A centralized multi-layer database and AI interface for DNA methylation research.

bioRxiv : the preprint server for biology·2026
Same author

Extracellular matrix gene variants and susceptibility to sport-related musculoskeletal injuries.

Journal of applied genetics·2026

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.6K

MCT1 A1470T: a novel polymorphism for sprint performance?

Marek Sawczuk1, Lauren K Banting2, Paweł Cięszczyk3

  • 1Department of Physical Culture and Health Promotion, University of Szczecin, Poland.

Journal of Science and Medicine in Sport
|February 4, 2014
PubMed
Summary

The TT genotype of the monocarboxylate transporter 1 (MCT1) gene A1470T polymorphism is linked to elite sprint/power athletic performance. This finding suggests a genetic predisposition for explosive athletic abilities.

Keywords:
Athletic performanceEndurance athletesGenesMonocarboxylate transport protein 1Power athletesRunning

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

36.1K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

14.9K

Related Experiment Videos

Last Updated: May 3, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.6K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

36.1K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

14.9K

Area of Science:

  • Genetics
  • Sports Science
  • Human Physiology

Background:

  • The A1470T polymorphism in the monocarboxylate transporter 1 (MCT1) gene is a candidate marker for athletic performance.
  • MCT1 facilitates lactate and pyruvate transport, crucial for energy metabolism during physical activity.

Purpose of the Study:

  • To investigate the association between the MCT1 A1470T polymorphism and athletic status.
  • To compare genotype distributions and allele frequencies among endurance athletes, sprint/power athletes, and controls.
  • To examine the relationship between MCT1 genotype and athletes' competition level.

Main Methods:

  • Genotyping of the MCT1 A1470T polymorphism (rs1049434) in Caucasian participants.
  • Study groups included endurance athletes (n=112), sprint/power athletes (n=100), and sedentary controls (n=621).
  • Statistical analyses included Fisher's exact tests and multinomial logistic regression.

Main Results:

  • Sprint/power athletes showed a higher prevalence of the T allele and TT genotype compared to controls.
  • Sprint/power athletes were more likely to possess the TT genotype than endurance athletes.
  • Elite sprint/power athletes had a greater likelihood of having the TT genotype compared to national-level athletes.

Conclusions:

  • The MCT1 TT genotype is significantly associated with elite sprint/power athletic status.
  • These findings highlight a potential genetic influence on explosive athletic performance.
  • Further research is recommended to validate these results in diverse elite athlete populations.