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Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
Published on: October 28, 2014
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[Calcium homeostasis]
Monika Wieliczko1, Joanna Matuszkiewicz-Rowińska1
1Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnetrznych, Warszawski Uniwersytet Medyczny.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|February 5, 2014
Summary
The human body tightly regulates serum calcium levels using parathyroid hormone (PTH) and calcitriol (1,25(OH)2D). This review discusses the roles of these factors and key organs in maintaining calcium homeostasis.
Area of Science:
- Biochemistry
- Physiology
- Endocrinology
Background:
- The human body contains 1000-1500g of calcium, with 98-99% stored as hydroxyapatite in bones.
- Serum ionized calcium is critical for numerous physiological processes and is tightly regulated.
Purpose of the Study:
- To review the key factors and organs involved in calcium homeostasis.
- To explain the complex interplay regulating serum ionized calcium.
Main Methods:
- Literature review of factors and organs involved in calcium regulation.
- Discussion of the roles of parathyroid hormone (PTH) and calcitriol (1,25(OH)2D).
Main Results:
- Serum ionized calcium regulation involves a complex feedback loop.
- Parathyroid hormone (PTH), calcitriol (1,25(OH)2D), and ionized calcium itself are key regulators.
- The parathyroid glands, intestine, bone, and kidneys are primary sites of action.
Conclusions:
- Calcium homeostasis is maintained through the coordinated action of hormones and target organs.
- Understanding these regulatory mechanisms is essential for comprehending calcium-related disorders.
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