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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Double layer paclitaxel delivery systems based on bioresorbable terpolymer with shape memory properties.

Monika Musiał-Kulik1, Janusz Kasperczyk2, Anna Smola1

  • 1Center of Polymer and Carbon Materials, Polish Academy of Sciences, 34 M. Sklodowska-Curie, 41-819 Zabrze, Poland.

International Journal of Pharmaceutics
|February 5, 2014
PubMed
Summary

This study developed a double-layer matrix using a shape-memory terpolymer for controlled paclitaxel release. The material demonstrated regular degradation and even drug release, proving useful for anti-restenotic drug delivery systems.

Keywords:
Bioresorbable terpolymerControlled drug delivery systemsHydrolytic degradationPaclitaxelShape-memory polymer

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Bioresorbable polymers are crucial for controlled drug delivery systems.
  • Selecting appropriate drug carriers is essential due to diverse drug properties.
  • Terpolymers with shape memory properties offer unique characteristics for matrix development.

Purpose of the Study:

  • To evaluate a novel terpolymer for creating double-layer drug delivery matrices.
  • To assess the terpolymer's suitability as an anti-restenotic drug vehicle.
  • To investigate paclitaxel release from double-layer systems for potential stent applications.

Main Methods:

  • Fabrication of double-layer matrices with a drug-free layer and a paclitaxel-containing layer.
  • In vitro degradation and drug release studies at 37 °C in phosphate-buffered saline (pH 7.4).
  • Characterization using gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and high-pressure liquid chromatography (HPLC) for paclitaxel quantification.

Main Results:

  • The terpolymer exhibited regular degradation patterns.
  • Consistent and even paclitaxel release profiles were observed.
  • The double-layer system allowed for modulation of drug release amounts.

Conclusions:

  • The studied terpolymer is a viable material for developing anti-restenotic drug delivery systems.
  • The double-layer matrix design enables tunable drug release for tailored therapeutic applications.
  • These findings support the development of advanced drug-eluting stents for various clinical needs.