Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Latitudes and Departures01:27

Latitudes and Departures

837
Latitudes and departures are essential concepts in surveying, providing a systematic way to analyze the projections of traverse lines. These projections allow surveyors to interpret a line's north-south and east-west components, which are crucial for precisely calculating areas, bearings, and lengths. Latitude is the north-south projection of a line, calculated as the product of the line's length and the cosine of its bearing. Departure, conversely, is the east-west projection obtained by...
837
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

2.9K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.9K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

1.4K
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
1.4K
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

931
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
931
Stages of Sleep01:22

Stages of Sleep

1.6K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.6K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.0K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity drives local CaMKII synthesis and subcellular localization via autophosphorylation-dependent pathways.

bioRxiv : the preprint server for biology·2025
Same author

Degradation of CaMKII is stimulated by its active conformation.

The Journal of biological chemistry·2025
Same author

Genetically-encoded markers for confocal visualization of single dense core vesicles.

Communications biology·2025
Same author

Genetically-encoded markers for confocal visualization of single dense core vesicles.

Research square·2024
Same author

Genetically-encoded markers for confocal visualization of single dense core vesicles.

bioRxiv : the preprint server for biology·2024
Same author

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep.

bioRxiv : the preprint server for biology·2023

Related Experiment Video

Updated: May 3, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.3K

Up all night on a redeye flight.

Leslie C Griffith1

  • 1Leslie C Griffith is an eLife reviewing editor, and is in the Department of Biology, Volen Center for Complex Systems, National Center for Behavioral Genomics, Brandeis University, Waltham, United States griffith@brandeis.edu.

Elife
|February 6, 2014
PubMed
Summary

A newly identified protein, RYE, plays a key role in regulating sleep. This discovery offers new insights into the biological mechanisms governing sleep-wake cycles.

Keywords:
Drosophilaacetylcholine signalingcyclinghomeostasissleepsleepless/Lynx-1

More Related Videos

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

3.5K
The FlyBar: Administering Alcohol to Flies
10:29

The FlyBar: Administering Alcohol to Flies

Published on: May 18, 2014

10.4K

Related Experiment Videos

Last Updated: May 3, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.3K
The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

3.5K
The FlyBar: Administering Alcohol to Flies
10:29

The FlyBar: Administering Alcohol to Flies

Published on: May 18, 2014

10.4K

Area of Science:

  • Neuroscience
  • Molecular Biology

Background:

  • Sleep regulation is a complex biological process involving multiple molecular pathways.
  • Understanding the proteins involved in sleep is crucial for addressing sleep disorders.

Purpose of the Study:

  • To investigate the function of the RYE protein in the context of sleep regulation.
  • To elucidate the molecular mechanisms by which RYE influences sleep.

Main Methods:

  • Utilized genetic manipulation techniques to alter RYE protein levels in model organisms.
  • Conducted behavioral assays to monitor sleep patterns and duration.
  • Performed molecular analyses to identify RYE's interacting partners and downstream targets.

Main Results:

  • Reduced RYE protein levels led to significant disruptions in sleep duration and architecture.
  • RYE was found to interact with key components of the sleep-wake regulatory network.
  • Specific molecular pathways regulated by RYE were identified, impacting neuronal activity during sleep.

Conclusions:

  • The RYE protein is a critical regulator of sleep.
  • RYE's function is essential for maintaining normal sleep patterns.
  • Targeting RYE may offer novel therapeutic strategies for sleep disorders.