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Modifying tumor-associated macrophages: An important adjunct to immunotherapy

Zvi G Fridlender1, Steven M Albelda2

  • 1Institute of Pulmonary Medicine; Hadassah-Hebrew University Medical Center; Jerusalem, Israel ; Thoracic Oncology Laboratory; University of Pennsylvania; Philadelphia, PA USA.

Oncoimmunology
|February 6, 2014
PubMed

The therapeutic success of immunotherapy requires specific alterations of the tumor microenvironment and/or the inhibition of tumor-elicited immunosuppression. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment. We have recently shown that modulating TAMs dramatically augments the efficacy of immunotherapy. TAM-activating agents should hence be considered as an addition to immunotherapy in future clinical trials.

Keywords:
DMXAAimmunotherapylung cancertumor associated macrophagesvaccines

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