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Published on: December 8, 2023
New limonoids from Coptidis Rhizoma-Euodiae Fructus couple
Ping Qian1, Hong-Wei Jin, Xiu-Wei Yang
1a State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines , School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University , Beijing 100191 , China.
Abstract:
A pair of inseparable new limonoids, named euodirutaecins A and B, were isolated from the Coptidis Rhizoma-Euodiae Fructus couple, together with two new single compounds evodirutaenin A and shihulimonin A1, and the known limonoids rutaevin, limonin, 12α-hydroxyrutaevin, and alkaloids rutaecarpine and evodiamine. Structures of these compounds were identified by spectral analyses and quantum chemical computational method, and the six limonoids were also evaluated for cytotoxicities against NCI-N87 and Caco-2 cell lines.
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