Chemical synthesis of staphyloferrin A and its application for Staphylococcus aureus detection
Rajesh K Pandey1, Gregory G Jarvis, Philip S Low
1Department of Chemistry, Purdue University, 560 Oval Dr, West Lafayette, IN 47907, USA. rkpandey1@yahoo.com plow@purdue.edu.
Organic & Biomolecular Chemistry
|February 7, 2014
Abstract:
The chemical synthesis of staphyloferrin A, a siderophore used by Staphylococcus bacteria for ferric iron retrieval, has been achieved with 79% yield via solid phase peptide synthesis (SPPS). Biological activity of synthetic staphyloferrin A has been confirmed by demonstrating its capture and uptake by live S. aureus.
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