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Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
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A rolling circle amplification-based DNA machine for miRNA screening coupling catalytic hairpin assembly with DNAzyme
Junyang Zhuang1, Wenqiang Lai, Guonan Chen
1Key Laboratory of Analysis and Detection of Food Safety (Ministry of Education & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, P.R. China. dianping.tang@fzu.edu.cn.
Chemical Communications (Cambridge, England)
|February 7, 2014
Abstract:
A novel DNA nanomachine based on the linear rolling circle amplification strategy was designed for sensitive screening of microRNA (miRNA) at an ultralow concentration coupling catalytic hairpin assembly (CHA) with DNAzyme formation.
