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Changes in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure in men and women
Ivan Marjanović1, Antonio Martinez2, Marija Marjanović3
1School of Medicine, University of Belgrade, Belgrade, Serbia. ivanmarjanovic007@yahoo.com
Srpski Arhiv Za Celokupno Lekarstvo
|February 8, 2014
Summary
Retrobulbar arterial circulation differs between men and women with primary open-angle glaucoma after intraocular pressure reduction. Vascular factors significantly impact optic disc perfusion in glaucoma patients.
Area of Science:
- Ophthalmology
- Vascular Biology
- Glaucoma Research
Background:
- Altered optic nerve head perfusion is a suspected cause of glaucoma.
- Primary open-angle glaucoma (POAG) affects retrobulbar arterial circulation.
Purpose of the Study:
- To assess hemodynamic changes in retrobulbar arteries after reducing intraocular pressure (IOP) in POAG patients.
- To investigate sex-based differences in vascular response to IOP reduction.
Main Methods:
- Color Doppler imaging of ophthalmic, central retinal, and posterior ciliary arteries.
- Study included 60 POAG patients (>50 years) with treated elevated IOP.
- Analysis of hemodynamic parameters: peak-systolic velocity, end-diastolic velocity, Pourcelot resistivity index, and pulsatility index.
Main Results:
- Women showed increased end-diastolic velocity in all vessels and decreased pulsatility index.
- Men exhibited decreased peak-systolic velocity, end-diastolic velocity, and pulsatility index in all vessels.
- Significant sex-specific changes observed in ophthalmic artery parameters.
Conclusions:
- Retrobulbar arterial circulation responses to IOP reduction differ between sexes in POAG.
- Vascular factors play a crucial role in supplying the optic disc neuroretinal rim.
- Understanding these vascular differences may inform glaucoma management strategies.
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